Zofran
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The active ingredient in ZOFRAN tablets and ZOFRAN oral solution is ondansetron hydrochloride as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT3 receptor type. Chemically it is (±) 1, 2, 3, 9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate.

What is Zofran Tablets used for?

Zofran Tablets contain a medicine called ondansetron. This belongs to a group of medicines called serotonin receptor-3 antagonists.

Zofran Tablets are used to help stop the nausea (sick feeling) and vomiting which can occur after medical treatments and operations.

Zofran Tablets should only be used to treat the nausea and vomiting for which they have been prescribed.

Each 4-mg ZOFRAN tablet for oral administration contains ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron. Each 8-mg ZOFRAN tablet for oral administration contains ondansetron hydrochloride dihydrate equivalent to 8 mg of ondansetron. Each tablet also contains the inactive ingredients hypromellose, iron oxide yellow (8-mg tablet only), lactose, magnesium stearate, microcrystalline cellulose, pregelatinized starch, triacetin, and titanium dioxide.

Each 5 mL of ZOFRAN oral solution contains 5 mg of ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron. ZOFRAN oral solution contains the inactive ingredients citric acid anhydrous, purified water, sodium benzoate, sodium citrate, sorbitol, and strawberry flavor.

Call your doctor at once if you have a serious side effect such as:

blurred vision or temporary vision loss (lasting from only a few minutes to several hours); severe dizziness, feeling short of breath, fainting, fast or pounding heartbeats; slow heart rate, trouble breathing; anxiety, agitation, shivering; feeling like you might pass out; or

You must not take Zofran Tablets if:

you are taking apomorphine (used to treat Parkinson's disease). you have ever had an allergic reaction to ondansetron or any of the ingredients listed toward the end of this leaflet. (See "Ingredients") you are pregnant, trying to become pregnant or breastfeeding, unless your doctor says it is safe. the expiry date (EXP) printed on the pack has passed. the packaging is torn or shows signs of tampering.
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